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To understand better how these variants influence platelet function, we created pluripotent stem cells from blood mononuclear cells in genotyped GeneSTAR subjects and then transformed the stem cells to megakaryocytes, the source of platelets in the bone marrow. We have determined the entire transcriptome of these megakaryocytes to measure gene expression levels in an effort to functionally link genetic variation with platelet function. We are also interested in epigenetic effects which regulate the amount of gene transcription and resulting protein formation.

We have done similar transcriptomic and proteomic studies in blood platelets as we have in stem cell-derived megakaryocytes. Our goal is to identify new therapeutic targets for drug development to control excessive platelet aggregation and reduce the risk of heart attack in susceptible individuals. We also hope to use the genetic information to predict who is at greatest risk for platelet aggregation or bleeding, and tailor treatment to effectively apply individualized precision medicine.

Research Areas: post-ischemic myocardial inflammation , effects of mental stress on the heart , cardiology , genetics of premature coronary artery disease , myocardial infarction. Lewis Becker, M.

Home - Cardiovascular Diagnosis and Therapy

We are interested in basic mechanisms of striated muscle biology. Drosophila melanogaster, the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. We investigate conserved myopathic muscle disease processes and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself.

He studies the identification and manipulation of age- and mutation-dependent modifiers of cardiac function, hierarchical modeling and imaging of contractile machinery, integrative analysis of striated muscle performan Research Areas: muscle development , genetics , myopathic processes , striated muscle biology , muscle function , myopathy , muscle physiology. Anthony Cammarato, Ph.

Platelet Function

The Cardiac Bioelectric Systems Laboratory research focuses on both the physiological and pathophysiological function of cardiac cells at a multicellular, syncytial level. We use cell culture models in a manner akin to mathematical models in which elements of the model can be designed, synthesized or controlled. Our traditional approach consists of cultured, confluent monolayers of cardiac cells that number in the tens of thousands to a million.

These cell monolayers can be engineered in terms of their tissue architecture, cell type, protein expression and microenvironment, and have been used to study clinically relevant phenomena in the heart that include electrical stimulation, electrical propagation, arrhythmia and cell therapy.

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Research Areas: bioelectric systems , arrhythmia , cell therapy , cardiology. Leslie Tung, Ph. Biomedical Engineering. The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the applications of advanced imaging techniques for arrhythmia management. The primary limitation of current fluoroscopy-guided techniques for ablation of cardiac arrhythmia is the inability to visualize soft tissues and 3-dimensional anatomic relationships. Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visualizing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation.

Menekhem M.

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Zviman, PhD is the laboratory manager. Research Areas: magnetic resonance imaging , CPR models , cardiac mechanics , MRI-guided therapy , ischemic tachycardia , arrhythmia , cardiology , sudden cardiac death , cardiopulmonary resuscitation , computational modeling. Henry Halperin, M.

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Research Areas: cardiac imaging , cardiac computing tomography , coronary risk prediction , heart attack prevention. Armin Arbab-Zadeh, M. The Foster Lab uses the tools of protein biochemistry and proteomics to tackle fundamental problems in the fields of cardiac preconditioning and heart failure.

Assessment, Diagnosis, and Treatment

Protein networks are perturbed in heart disease in a manner that correlates only weakly with changes in mRNA transcripts. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism.

Platelet Plug (Primary Hemostasis) - How The Clot Forms!

Understanding the status of protein networks in the diseased state is, therefore, key to discovering new therapies. Brian Foster, Ph. Research Areas: proteomics , protein biochemistry , heart failure , cardiology , cardiac preconditioning , cardiomyopathy. Brian Foster, M. The main focus of Dr. Gilotra's research is understanding the pathophysiology and outcomes in inflammatory cardiomyopathies including myocarditis and sarcoidosis, as well as improvement of heart failure patient care through noninvasive hemodynamic monitoring and studying novel strategies to reduce heart failure hospitalizations.

Additional investigations involve clinical research in advanced heart failure therapies including heart transplantation and mechanical circulatory support. Research Areas: heart failure , cardiology , cardiomyopathy.

Platelet Function

Nisha Gilotra, M. The Institute for Computational Medicine's mission is to develop quantitative approaches for understanding the mechanisms, diagnosis and treatment of human disease through biological systems modeling, computational anatomy, and bioinformatics. Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke.

In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers.

The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.